Monthly Archives: January 2019

The Senolytic for Senescent Cells

Fisetin is ideal at reducing inflammation and enhancing the functions of the brain. There are numerous ways through which fisetin can promote your health and prevent diseases. Before learning about all those, you may first want to know more about the compound itself.

studying fisetin

Fisetin: What is it?

This is a flavonol chemical belonging to the flavonoid group of polyphenols. It is one of the plant pigments that give color to various fruits and vegetables.

Reduce How We Age

Senescence is the number one reason for aging. This means that as age catches up, your cells will halt its replication effects. If your cells cannot divide, they generally become useless in the body and just accumulate to cause inflammation. This will slowly impair functions of the cells and increase the risks of contracting age-related diseases.

One of the main reasons behind the spirited efforts of anti-aging scientists to explore more ways of inhibiting senescence is just due to the fact that is a debilitating period in life. Senolytic compounds like flavonoid fisetin, on the other hand, usually have the properties of reversing or slowing down aging by clearing the old damaged cells in our bodies.

Fisetin Extends Longevity

Numerous studies have continued to find the role of fisetin in activating SIRT-1. This gene has been associated with increasing lifespan. We all know that there are seven sirtuins in the human body. SIRT 1, on the other hand, is particularly good for conferring healthy aging.
According to some of the pre-clinical studies conducted on mice, besides the healthy aging benefits, sirt1 was also found to protect against metabolic syndrome that is induced by high fat diets. This is usually characterized by fatty liver and obesity. Fisetin, a flavonoid occurring naturally in fruits and vegetables has been shown to activate the sirt1 gene.

Fisetin Can Lower Body Weight

When used for pre-clinical tests in mice, the supplementation of fisetin was highly effective in reversing the weight gained from high fat diets. This is a potential benefit to how we can use fisetin to maintain healthy body weights. It should be noted that obesity is one of the lifestyle conditions crippling the current society. Obesity is immensely associated with many other conditions including cardiovascular diseases.

Protecting the Skin from Sun Damage

There are a number of genes that result in skin aging. Interestingly, nearly all of the genes are activated by UVB exposure. Fisetin works by lowering how these genes express themselves. It inhibits the degradation of collagen caused by exposure to UVB. This is a key factor in the aging of our skin. It is highly essential in lowering reactive oxygen species caused by UV rays at the cellular levels. This is besides lowering prostaglandin E2 as well as generation of nitric acid generation.

In essence, the craze being witnessed at the moment to try out different senolytics is not in vain. There are proven scientific studies to the benefits some of those compounds can bring in our bodies. A good rule of thumb involves choosing diets that are rich in these compounds. This can go a long way to boost natural bio-availability of senolytics in our bodies. However, supplementing is a more sustainable solution to meet various dietary requirements of these compounds.